High-strength, porous additively manufactured implants with optimized mechanical osseointegration.

TitleHigh-strength, porous additively manufactured implants with optimized mechanical osseointegration.
Publication TypeJournal Article
Year of Publication2021
AuthorsCN Kelly, T Wang, J Crowley, D Wills, MH Pelletier, ER Westrick, SB Adams, K Gall, and WR Walsh
JournalBiomaterials
Volume279
Start Page121206
Date Published12/2021
Abstract

Optimization of porous titanium alloy scaffolds designed for orthopedic implants requires balancing mechanical properties and osseointegrative performance. The tradeoff between scaffold porosity and the stiffness/strength must be optimized towards the goal to improve long term load sharing while simultaneously promoting osseointegration. Osseointegration into porous titanium implants covering a wide range of porosity (0%-90%) and manufactured by laser powder bed fusion (LPBF) was evaluated with an established ovine cortical and cancellous defect model. Direct apposition and remodeling of woven bone was observed at the implant surface, as well as bone formation within the interstices of the pores. A linear relationship was observed between the porosity and benchtop mechanical properties of the scaffolds, while a non-linear relationship was observed between porosity and the ex vivo cortical bone-implant interfacial shear strength. Our study supports the hypothesis of porosity dependent performance tradeoffs, and establishes generalized relationships between porosity and performance for design of topological optimized implants for osseointegration. These results are widely applicable for orthopedic implant design for arthroplasty components, arthrodesis devices such as spinal interbody fusion implants, and patient matched implants for treatment of large bone defects.

DOI10.1016/j.biomaterials.2021.121206
Short TitleBiomaterials