High-Strength Hydrogel Attachment through Nanofibrous Reinforcement.

TitleHigh-Strength Hydrogel Attachment through Nanofibrous Reinforcement.
Publication TypeJournal Article
Year of Publication2021
AuthorsJ Zhao, A Kirillova, CN Kelly, H Xu, WJ Koshut, F Yang, K Gall, and BJ Wiley
JournalAdvanced Healthcare Materials
Start Pagee2001119
Date Published02/2021

The repair of a cartilage lesion with a hydrogel requires a method for long-term fixation of the hydrogel in the defect site. Attachment of a hydrogel to a base that allows for integration with bone can enable long-term fixation of the hydrogel, but current methods of forming bonds to hydrogels have less than a tenth of the shear strength of the osteochondral junction. This communication describes a new method, nanofiber-enhanced sticking (NEST), for bonding a hydrogel to a base with an adhesive shear strength three times larger than the state-of-the-art. An example of NEST is described in which a nanofibrous bacterial cellulose sheet is bonded to a porous base with a hydroxyapatite-forming cement followed by infiltration of the nanofibrous sheet with hydrogel-forming polymeric materials. This approach creates a mineralized nanofiber bond that mimics the structure of the osteochondral junction, in which collagen nanofibers extend from cartilage into a mineralized region that anchors cartilage to bone.

Short TitleAdvanced Healthcare Materials